抗敏口服液的毒性及药效学实验研究

TOXICOLOGICAL AND PHARMACODYNAMIC EXPERIMENT ON KANG MIN KOU FU-YE

小鼠24小时口服抗敏口服液176g/kg(相当于临床用量的160倍),观察7天,未见不良反应;大鼠口服33g/kg(每日用帚相当于临床用量的30倍),连续用药90天。大鼠肝肾功能(SGPT及BUN值)和血象无明显不同。各给药组用药后体重均明显增加,与对照组比较增重的差别无显著性(p>0.05),说明该制剂对大鼠的生长发育无抑制作用;解剖肉眼观察及镜检,大鼠心、肝、肾组织未见病理学改变。该制对剂组胺所致的局部皮肤反应和肠肌收缩反应均有明显抑制作用。该制剂对PCA、DNCH所致的皮肤反应及鸡蛋白所致的休克有明显的对抗作用。比较实验发现,该制剂抗组胺效应较息斯敏快、强,但维持时间较短。

No untoward reaction Was found on mice days after 176g/kg of Kang Min Kou fu-ye (160 tithes of clinical dose) Were administered. 33g/kg/day of this drug Was fed to rats for 90 consecutive days (30 times of clinical dose), no effect Was found on animals'liver function, kideney function, and blood picture; no intoxicational pathological change Was observed in their heart, liver and kidney under light microscope. The Preparation can significantey inhibit not only the guinea pigs' local skin rection and the contraction reaction of rabbits'intestinal smooth muscle caused by histamine, but also the skin reaction of guinea pig caused by PCA and DNCB. The preparation can resist allergic shock caused by egg white. Its antihistamine effect is more rapid, strong, but the time is shorter than that of Astemizole.