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组织蛋白酶B研究进展 被引量：13

The Progress of Study on the Cathepsin B
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摘要 组织蛋白酶B(cathepsinB:EC3.4.22.1)是溶酶体内半胱氨酸内切蛋白水解酶,其作用非常广泛,参与机体多种生理、病理过程.尤为重要的是,它能促进肿瘤细胞浸润转移,因此成为目前诊断、治疗恶性肿瘤的研究热点.综述了组织蛋白酶B的生物学特性、基因与蛋白结构特点、表达调控机制,以及应用方面的研究. Cathepsin B(CB:EC 3.4.22.1)is a lysosomal cysteine endoproteinase which participate in many physiological and pathological events.Above all,it can promote invasion and metastasis of the tumor cells.So diagnosing and curing the malignancy are increasingly focused on.It was discussed on the biological feature of cathepsin B,the physiological and pathological functions,the character of gene and protein,the mechanism of expression and regulation,as well the status in application in this review.
作者 卢士英 任洪林 柳增善 赵广英 华育平
机构地区 东北林业大学野生动植物资源学院 解放军军需大学军事兽医系
出处 《河北师范大学学报（自然科学版）》 CAS 2004年第3期306-309,共4页 Journal of Hebei Normal University：Natural Science
关键词 组织蛋白酶B 生物学特性 肿瘤细胞 浸润转移 病理功能 表达调控机制 cathepsin B biological feature gene and protein application
分类号 R730 [医药卫生—肿瘤] Q556.9 [生物学—生物化学]
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参考文献16

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二级参考文献68

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共引文献102

同被引文献137

  • 1刘阳,周竹青,梅方竹,周广生,蔡静桐,杨文丽,张智慧.小麦颖果与根部Cathepsin B-like蛋白的初步研究[J].湖北农业科学,2013,52(17):4044-4047. 被引量：2
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  • 3曾广智,谭宁华,贾锐锐,潘蓄林.组织蛋白酶及其抑制剂研究进展[J].云南植物研究,2005,27(4):337-354. 被引量：30
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引证文献13

二级引证文献32

河北师范大学学报（自然科学版）
2004年 第3期

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