灯盏细辛对老年肺源性心脏病血液流变学的影响

Effect of Erigeron breviscapine on hemorheology of senile pulmonary heart disease

目的 观察灯盏细辛治疗老年肺源性心脏病 (肺心病 )的疗效及其对血液流变学的影响。方法 将 70例老年肺心病急性加重期患者随机分为A ,B两组。A组 (36例 )在常规治疗的基础上加用灯盏细辛注射液 ,连用 2周 ;B组 (34例 )仅予常规治疗。结果 A组血液流变学示低切与高切变率下全血黏度、血浆比黏度、红细胞聚集指数、红细胞电泳时间、红细胞比积、血小板聚集率及纤维蛋白原量均有显著性下降 (P <0 .0 5 ) ,与B组比较亦有显著性差异 (P均 <0 .0 5 )。临床总有效率及显效率A组分别为 91.7%和 5 0 .0 % ;B组为 70 .6 %及 2 6 .2 %。A组疗效明显优于B组 (P <0 .0 5 )。治疗期间未见灯盏细辛不良反应。结论 灯盏细辛能显著改善慢性肺心病急性加重期患者的血液流变性 ,是辅助治疗肺心病的一种有效而安全的药物。

Objective It is to observe the therapeutic efficacy of Erigeron breviscapine on senile pulmonary diseace (SPD) and the effect of it on hemorheology.Methods Seventy patients with acute aggravation of SPD were randomly divided into group A (36 patients) and group B (34 patients). The patients in group A were treated with Erigeron breviscapine based on conventional treatment for two weeks. The patients in group B were treated with conventional treatment only.Results Whole blood viscosity, plasma rate viscosity, erythrocyte aggregation index, erythrocyte electrophoresis time and erythrocyte specific volume, platelet aggregation rate and fibrinogen under low or high shear rate in group A were observably reduced than that before treatment and in group B (P<0.05). The clinical total effective rate and obvious effective rate in group A (91.7% and 50.0%) were higher than those in group B (70.6% and 26.2%) (P<0.05). No side-effects were found in treating with Erigeron breviscapine.Conclusion Erigeron breviscapine can obviously improve blood rheology in patients with acute aggravation of SPD. It is one of effective and safe drugs for assistant treatment of SPD.