肢体缺血再灌注后肺损伤变化及牛磺酸对其的影响

Pulmonary changes following limbs ischemia reperfusion and effect of taurine on that

目的 观察大鼠肢体缺血再灌注 (LIR)后肺的损伤性变化及牛磺酸 (Tau)对其的影响。方法 实验采用大鼠LIR损伤模型 ,将Wistar大鼠随机分为对照组、缺血再灌注组 (IR组 )、Tau +IR组 ,分别测定 p(O2 )和 p(CO2 )、肺系数 (LI)和肺通透指数 (LPI) ,光镜和透射电镜观察肺组织形态学变化。结果 Tau +IR组在改善肺呼吸功能、减轻组织水肿及中性粒细胞的聚集方面均显著优于其他两组。结论 Tau对大鼠止血带休克后继发的肺损伤具有保护作用。

Objective It is to observe the pulmonary injury changes following limbs ischemia reperfusion (LIR) and the effect of taurine (Tau) on that.Methods The LIR injury rat models were adopted in the experiment. Wistar rats were randomly divided into control group, ischemia reperfusion (IR) group and Tau+IR group. Then the changes of arterial blood gas level, lung index (LI) and lung permeability index (LPI) were measured and the morphological changes of the lung tissues were observed through light microscope and transmission electron microscope.Results Compared with the other groups, the lung respiratory function was improved, the tissue edema was alleviated and the neutrophil assembling was decreased in Tau+IR group.Conclusion Tau has protective effect on the pulmonary injury changes following LIR.