0.5%脂质体鬼臼毒素壳聚糖膜剂制备配方的优选

Selection of the Formula of the 0.5% Liposome Podophyllotoxin Chitosan Film

目的 探讨 0 5 %脂质体鬼臼毒素壳聚糖膜剂制备的最佳配方。方法 选择制备壳聚糖膜剂所需的壳聚糖、醋酸、明胶作为三个因素 ,每个因素三水平 ,0 5 %脂质体鬼臼毒素作为空白因素 ,通过正交实验设计 ,制备不同配方的药膜 ,以粘附性、溶解性作为评价指标进行综合评价 ,确定最佳的膜剂配方 ;根据得出的配方制膜并对其粘附性及溶解性进行测定。结果 通过对各配方膜剂的综合评价进行统计分析得出 2 %壳聚糖、1%的醋酸、2 %的明胶、0 5 %的脂质体鬼臼毒素的配方为最佳配方。结论 根据正交实验的结果制备的药膜 ,在粘附性、溶解性方面均符合要求 ,且在成膜性。

Objective To explore the best formula of the 0 5% liposome podophyllotoxin chitosan film. Methods Chitosan,acetic acid and gelatin were selected as three factors to prepare film, each factor including three levels, and 0 5% liposome podophyllotoxin served as blank factor. The films of different formula were prepared according to orthogonal design. The evaluation was made on the basis of the characteristics of conglutination and dissolution, then the best formula was determined finally. Results The results showed that the conglutination and dissolution of the film which was made of 2% chitosan, 1%acetic acid, 2% gelatin and 0 5% liposome podophyllotoxin chitosan was the most perfect. Conclusion The film designed according to orthogonal experiment was coincidenced with the requirements in aspect of conglutination and dissolution, and its appearance was perfect.