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Fas/Fasl系统与妊高征的关系 被引量：1

Relationship between Fas/Fasl system and pregnancy-induced hypertension
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摘要 死亡因子Fas与其配体Fasl相结合可诱导细胞凋亡 ,这一过程作为组织更新手段伴随着胎盘的发育 ,正常妊娠Fas/Fasl表达与胎盘生长、滋养细胞侵入均有关系 ,并在一定程度上达到平衡。妊娠高血压综合征时胎盘细胞凋亡增加 ,Fas/Fasl表达异常可部分解释胎盘浅着床和局部免疫反应增强 。 Cross-binding of death factor Fas and its ligand Fasl can induce apoptosis of cell, which is accompanied by placental development as a renovation means of the tissues. The expression of Fas /Fasl in normal pregnancy relates to placental growth and trophoblastic invasion. Moreover, they keep balanced to some extent. Increased apoptosis of placental cells in PIH was found. The abnormal expression of Fas /Fasl can partly explain why shallow implantation and increased immune response in placenta occur, but a further study on discordance between its sensitivity and expression is necessary.
作者 续靖宁 汪丹 秦利 苟文丽
机构地区 西安交通大学第一医院妇产科 宁夏武警医院妇产科
出处 《国外医学（妇幼保健分册）》 2004年第2期87-88,123,共3页 Foreign Medical Sciences (Section of Maternal and Child Health)
关键词 妊高征 凋亡 FAS/FASL pregnancy-induced hypertension apoptosis Fas /Fasl
分类号 R714.246 [医药卫生—妇产科学]
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参考文献20

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同被引文献12

  • 1岳秀云,张曦,崔世红,杨佩兰.Fas表达异常与重度子痫前期的关系研究[J].中国妇幼保健,2005,20(19):2508-2509. 被引量：1
  • 2胡文胜,王正平,董岳,王焓知.子痫前期患者血清和胎盘的Fas与FasL的变化及意义[J].浙江大学学报（医学版）,2005,34(6):499-502. 被引量：8
  • 3欧阳珊,乔福元.Fas在妊娠过程中表达变化的研究[J].中国优生与遗传杂志,2006,14(1):54-55. 被引量：1
  • 4Hammer A, Blaschitz A, Daxbock C. Fas and Fas - ligand are expressed in the uteroplacental unit of first -trimester pregnancy [J]. Am J Reprod Immunol, 1999, 41 (1) : 41.
  • 5Hammer A, Dohr G. Expression of Fas - ligand in first trimester and term human placental villi (J) . J Reprod Immunol, 2000, 46 (2): 83.
  • 6Iwama H, Akutsu H, Kuretake S. Serum concentrations of soluble Fas antigen and soluble Fas ligand in mother and newborn [J]. Arch Gynecol Obstet, 2000, 263 (3): 108.
  • 7Dannochwal - Kolarz D, Rolinski J, Leszczynska - Gorzelak B. Fas antigen expression on the decidual lymphocytes of pre - eclamptic patients [J]. Am J Reprod Immunol, 2000, 43 (4) : 197.
  • 8Kauma SW, Huff TF, Hayes N. Placental Fas ligand expression is a mechanism for maternal immune tolerance to the fetus [J]. J Clin Endocrinol Metab, 1999, 84 (6): 2188.
  • 9Darmochwal - Kolarz D, Leszczynska - Gorzelak B, Rolinski J. The expression and concentrations of Fas/APO - 1 ( CD95 ) antigen in patients with severe pre - eclampsia [ J] . J Reprod Immunol, 2001, 49 (2): 153.
  • 10Allaire AD, Ballenger KA, Wells SR. Placental apoptosis in preeelampsia [J]. Obstet Gynecol, 2000, 96 (2): 271.

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国外医学（妇幼保健分册）
2004年 第2期

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