欣母沛治疗产后出血的临床研究

A clinical study on controlling atonic postpartum hemorrhage with hemabate sterile solution

目的 :观察欣母沛 (氨丁卡前列素 )用于治疗宫缩乏力所致的产后出血的疗效。方法 :对宫缩乏力所致的产后出血患者用常规方法治疗无效后 ,采用欣母沛宫体或宫颈注射 ,重复使用可间隔 15分钟。结果 :38名患者 ,36例有显著效果 ,有效率为 94 .7%。无效 2例 ,1例合并绒毛膜羊膜炎 ,另 1例并发DIC。结论 :欣母沛治疗宫缩乏力性产后出血效果显著 ,但应明确诊断 ,早期使用。

Objective: To observe curative effect of intrauterinely injected Hemabate sterile solution(15-methylprostaglandin F2a-tromethamine) for controlling atonic postpartum hemorrhage. Methods: The women who had postpartum hemorrhage caused by uterine atony were conducted an injection of Hemabate sterile solution intrauterinely or intracervically, after no response to conventional thearapies.The time interval between multiple doses is about 15 minutes. Results: The hemorrhage was successfully controlled immediately after administration of Hemabate sterile solution in 36 of 38 cases.The effective rate was 94.7%.Two cases failed, of which one patient was complicated by chorioamnionitis, and the another one was complicated by disseminated intravascular coagulation(DIC). Conclusion: Hemabate sterile solution appeared very effective for treatment of severe atonic postpartum hemorrhage and had few side effects under condition of determined diagnosis and early administration of the drug.