摘要
瘦素是肥胖基因的蛋白产物 ,由 16 7个氨基酸组成 ,分子量为 16kDa。在人体主要由脂肪组织合成和分泌。后来人们又发现胎盘及胎儿也可产生瘦素。研究者通过放射免疫法 (RIA)、酶联免疫吸附试验 (ELISA)、逆转录 -聚合酶链反应 (RT PCR)等方法测定血清、脐血、羊水的瘦素浓度及胎盘瘦素mRNA的表达水平。瘦素水平与孕妇体重、体重指数、脂肪积累 ,胎儿的生长发育、脂肪沉积等均有关。近几年来人们研究发现 ,瘦素与妊娠高血压综合征、胎儿宫内生长发育异常、妊娠期糖尿病等一些产科疾病有关。瘦素浓度的变化对这些疾病的早期诊断、及时治疗及预后判断均起一定的作用。也许在不久的将来 。
Leptin, a protein product of obese gene, is composed of 167 amino acids and its molecular weight is 16 kDa. In human body, leptin is mainly synthesized and secreted by adipose tissues. Later, researchers found that placenta and fetus can produce leptin, too. And leptin concentrations in serum, umbilical blood, amniotic fluid and mRNA expression levels of leptin in placenta can be detected by radioimmunoassay(RIA), enzyme-linked immunosorbent assay(ELISA), RT-polymerase chain reaction(RT-PCR)and so on. Leptin level relates to body weight, body mass index, fat accumulation of pregnant women, fetal growth and development and fetal fat deposit. In recent years, it was considered that leptin is associated with pregnancy-induced hypertension syndrome(PIH), fetal intrauterine growth retardation(IUGR), gestational diabetes mellitus(GDM). The detection of changes in leptin concentrations is of clinical significance for early diagnosis, timely treatment and prognosis of these diseases. Maybe, in near future, leptin can become an important medicine to be used in clinic. In a word, leptin plays a very important role in obstetrics. We summarized progress in study on leptin as follows.
出处
《国外医学（妇幼保健分册）》
2004年第2期119-121,共3页
Foreign Medical Sciences (Section of Maternal and Child Health)
