铜(Ⅱ)、铁(Ⅱ)、锰(Ⅱ)半胱氨酸配合物的合成及其超氧化物歧化酶活性

Synthesis and Free Radical Inhibition Rate of Copper(Ⅱ), Iron(Ⅱ)、Manganese(Ⅱ) Complexes with Cysteine

合成了半胱氨酸与铜( )、铁( )、锰( )三种金属离子的配合物,铜( )-半胱氨酸、Fe( )-半胱氨酸和Mn( )-半胱氨酸模拟超氧化物歧化酶。用差热分析(DTA)测定了热稳定性;通过元素分析、红外光谱初步测定了配合物的组成和结构;利用改进核黄素光还原氯化硝基四氮唑蓝(NBT)法测定了三种配合物催化歧化超氧阴离子自由基(O·-2)反应的活性。研究表明:合成配合物结构稳定,水溶液中具有一定的SOD样活性,在医学及生物学上可能具有一定的应用前景。

Three cysetine complexes Cu-cysteine、Fe-cysteine and Mn-cysteine, were synthesized. The compositions and structures of the complexes were characterized by elemental analyses, DTA and IR spectrascopy. The SOD like activities were measured by the method based on the reduction of nitro blue terrazolium (NBT) by lactoflavin. The result showed that these analogues of SOD have good SOD like activities.