小儿重症颅脑疾患脑脊液和血清脑型肌酸激酶同功酶的研究

Clinical study of creatine kinase BB in serum and cerebrospinal fluid of childrem with serious craniocerebral disease

通过对42例小儿重症颅脑疾患患者脑脊液和血清脑型肌酸激酶同功酶的研究,发现在颅脑疾患患者,其水平显著高于对照组。脑脊液与血清中该酶水平与脑组织损伤的程度密切相关,可作为判断损伤程度和预后的可靠生化指标。若脑脊液该酶活力显著增高且持续下降则提示预后不良。

Creatine kinase BB(CK-BB)activity in serum andcerebrospinal fluid was measured in 42 patients with seri-ous craniocerbral disease and was found to be remarkablyelevated.The level of CK-BB in serum and cerebrospinalfluid were closely related with the severity of brain tissuedamage.We suggest that CK-BB activity arkably ele-vated.We suggest that CK-BB activity be used as a reli-able biochemical marker for evaluating the severity ofbrain damage and prognosis.The prognosis was poor inpatients with extremely s(?)stained high CK-BB activity.