联苯双酯对肾移植受者环孢素A全血浓度的影响及肝毒性的防护作用

Effects of bifendate on the blood concentration and hepatic toxicity of cyclosporine A in renal transplanted recipients

目的 :研究肾移植受者应用联苯双酯 (bifen date ,BFD)对环孢素A(cyclosporinA ,CsA)全血浓度的影响及肝毒性的防护作用。方法 :2 8例患者 (合用组 )合用CsA与BFD ,30例患者 (对照组 )单服CsA ,以CsA全血浓度及肝功能作为临床评价指标。结果 :BFD能有效降低肾移植受者异常升高的ALT和AST ,合用BFD后CsA全血浓度与合用前比较降幅达 17.7% ,与对照组比较亦有显著性降低 (P <0 .0 1) ,停用BFD后CsA全血浓度明显升高 ,增幅达36 .3%。结论 :BFD能防护肾移植受者CsA肝毒性并能明显降低CsA血浓度。

AIM: To study the effects of bifendate on the blood concentration and hepatic toxicity of cyclosporine A in renal transplanted recipients. METHODS: 28 cases with renal transplantation in coadministration group were treated with CsA and BFD,and 30 cases with renal transplantation in control group received only CsA. Blood levels of CsA,biochemistry indexes for liver and renal function were determined. RESULTS: Blood concentrations of CsA in patients combined with BFD went down by 17.7 % compared with those before taking BFD and had a significant decrease compared with control group. Blood concentrations of CsA were significantly increased after stopping BFD administration. Mean blood concentrations were increased by 36.3 %. BFD could effectively reduce higher ALT and AST. CONCLUSION: BFD can markedly decrease the blood concentration of CsA in renal transplanted recipients.