流感病毒的核蛋白是一种多功能RNA结合蛋白

The influenza virus Nucleoprotein:A Multifunctional RNA-binding Protein

流感病毒核蛋白 (NP)的主要功能是使病毒基因组衣壳化 ,以便 RNA转录、复制和病毒子装配。本综述的目的是说明 NP不仅是一种RNA结合的结构蛋白 ,而且作为病毒与宿主细胞之间的一种关键的配体分子而起作用 ,通过病毒和细胞的大分子之间相互作用来发挥其功能 ,包括 RNA、NP、病毒 RNA依赖的 RNA聚合酶和病毒基质蛋白。 NP也与细胞多肽相互作用 ,细胞多肽包括肌动蛋白、细胞核输入和输出装置所需的成分和细胞核

The primary function of the influenza virus nucleoprotein(NP) is to encapsidate the virus genome for the purposes of RNA transcription,replication and packing.The purpose of this review is to illustrate by using the influenza virus NP as a well-studied example that the molecule is not only a structure RNA-binding protein,but also functions as a key adapter molecule between virus and host cell processes.It does so through the ability to interact with a wide variety of viral and cellular macromolecules,including RNA,itself,two subunits of the viral RNA-dependent RNA polymerase and the viral matrix protein.NP also interacts with cellular polypeptides,including actin,components of the nuclear import and export apparatus and a nuclear RNA helicase.