摘要
布鲁氏菌病是由布鲁氏菌属的细菌引起的人畜共患传染病 ,目前布鲁氏菌属的细菌主要有七个种。随着分子生物学技术的发展 ,对布鲁氏菌的致病机制在分子水平上有了更进一步的理解 :布鲁氏菌自身一些与致病有关的基因使得布鲁氏菌逃避了巨噬细胞的杀伤作用 ,在巨噬细胞内存活和定居。在布鲁氏菌病免疫过程中 ,先天性免疫应答主要通过补体、巨噬细胞、天然杀伤细胞来参与 ,获得性免疫应答中 ,CD4+ 、CD8+ 、rδT细胞起很重要的作用。文章围绕这些与致病、免疫有关的基因及参与免疫反应细胞的研究进展进行了探讨 ,可为今后进行布鲁氏菌病预防及开发新型基因工程苗提供理论依据。
Brucellosis is a zoonotic disease,which is infected with Brucella.Seven species of Brucella have been found. With the development of molecular biotechneque,it is possible for us to further understand pathogenesis,because Brucella contains some pathengic genes which make brucella escape killness from macrophagocyte and have capibility to survive in macrophagocyte.In the course of immunity for brucellosis,macrophagocyte, NK cell and complement are involved in innate immunity. CD4^+、CD8^+ and rδ T cell play important roles in adaptive immunity. The article focused on both genes relating to pathogen and immunity and cells associating to immunity reaction,then gave us a theoretic undergrand: how to provent brucellosis and efficiently develop gen-engineering vaccine.
出处
《动物医学进展》
CSCD
2004年第3期62-65,共4页
Progress In Veterinary Medicine
