冠状动脉病变程度与冠心病猝死间关系的实验研究

Extent of Coronary Stenosis and the Sudden Coronary Death

本实验用27只日本大耳白家兔通过饲喂胆固醇的方法,诱发动物发生心脏冠状动脉粥样硬化。实验分三组,11只为重病变组,饲喂17周胆固醇1g/天;10只为轻病变组,饲喂13周胆固醇1g/天;6只为对照组,喂基础饲料。实验结束时,所有动物均静注大剂量肾上腺素(50μg/kg),重病变组出现了复杂性室性早搏。三组动物的病变积分值与室性早搏Lown氏级分值呈正相关关系。重病变组猝死率高于轻病变组。本实验表明,在体内儿茶酚胺增多时,冠状动脉病变程度越重其猝死率越高。

Twenty-seven male rabbits were divided into 3 groups, 11 rabbits as severe group, 10 rabbits as mild group, 6 rabbits as control group. Different entents of coronary stenosis were produced ty feeding cholesterol 1 g/d. for 17 weeks in severe group and for 13 weeks in mild group. After intravenous injection of adrenaline 50 μg/kg, all the rabbits presented kinds of severe arrhythnfia in severe group. There was positive correlation between the total accumulated number of coronary stenosis and the number of Lown's degree of ventricular premature complexes in 3 groups. The sudden death rate in severe group was higher than that in mild group. Our study indicates that higher endogenous catecholmines level higher the degree of coronary stenosis and higher the sudden death rate.