甲状腺肿瘤术前鉴别诊断的分子标志物研究进展

Advances in research on molecular biological markers for the differential diagnosis of thyroid neoplasms

甲状腺肿瘤是最常见的内分泌肿瘤之一。临床上甲状腺恶性肿瘤经常表现为无症状的甲状腺结节,术前甲状腺结节的良恶性鉴别诊断具有非常重要意义。分子生物学诊断方法可以用于术前甲状腺良恶性肿瘤的辅助鉴别诊断,提供一个更为合理的治疗方案。本文综述几种近年来研究较多的用于甲状腺肿瘤鉴别诊断的分子生物学标志物VEGF-C,Cytokeratin-19,HBME-1,Pax8-PPAR和Galectin-3进展。

Thyroid neoplasm is one of the most common endocrinal tumors. In general, thyroid cancer patients are usually presented with asymptomatic neck nodules. A differential diagnosis between malignant and benign thyroid neoplasm is very important for these patients. This review article primarily discusses biological markers used to aid the differential diagnosis of thyroid neoplasia, which may lead to a more rational approach to the treatment. It mainly describes the recent development of molecular biological markers VEGF-C, Cytokeratin-19, HBME-1, Pax8-PPAR and Galectin-3 for the differential diagnosis of thyroid neoplasms.