米索前列醇预防产后出血的作用

The Role of Misoprostol in the Prevention of Postpartum Hemorrhage

目的:探讨米索前列醇用于预防产后出血的可行性及意义。方法:选择同期单胎头位足月妊娠阴道分娩的初产妇100例,随机分为米索前列醇组与催产素组各50例,在胎儿娩出后分别口服米索前列醇600μg和静注催产素20U,观察产后2h出血发生率及出血量并进行比较。结果:产后出血发生率米索前列醇组为0％(0/50),催产素组为6％(3/50),有显著差异(P<0.01)。米索前列醇组平均出血量为157±80ml。催产素组平均出血量为245±97ml,两组有显著差异(P<0.01)。结论:米索前列醇组产后出血发生率及出血量明显少于催产素组,可以有效预防产后出血。

Objective: To explore the feasibility and safety of misoprostol used in prevention of postpartum hemorrhage. Methods: 100 women were randomized into two groups, as follows: Group 1 received oral misoprostol 600 micro g, Group 2 received intravenous infusion of oxytocin 20 IU. The incidence and amount of bleeding from before delivery to 2 hours postpartum were the main outcome measures. Results: The incidence of postpartum hemorrhage in group 1 was 0% (0/50) and in group 2 was 6% (3/50), P<0. 01. The average amount of bleeding in group 1 was 157 ± 80ml. and 245 ± 97ml in group 2, there are significant difference between two groups (P<0. 01). Conclusion: The incidence and amount of bleeding in using oral misoprostol was significantly less than using oxytocin. Oral misoprostol alone is more effective than oxytocin alone for the prevention of postpartum hemorrhage.