血清NO和sIL-2R在肝脏损伤发病机制中作用的探讨

The Role of Serum NO and sIL-2R in Pathogenesis of Liver Injury

目的:探讨肝脏疾病患者血清NO和sIL-2R在肝脏损伤发病过程中的作用。方法:分别采用亚硝酸盐还原试验、双抗体夹心Elisa法检测血清NO和sIL-2R。结果:急性肝炎、慢性肝炎、肝硬化和肝癌患者NO、sIL-2R明显高于对照组(P<0.01);各疾病组血清NO与sIL-2R成正相关。结论:NO和sIL-2R在肝脏损伤中起重要作用,检测NO、sIL-2R可以了解肝病患者的免疫功能及肝细胞损伤程度,有助于肝病患者的早期诊断和治疗。

Objective: To investigate the role of serum No and sIL - 2R in pathogenesis mechanism of liver injury. Methods: Serum NO and sIL- 2R were detected by nitrite reduction test and double - sandwich Elisa. Results: The levels in serum NO and sIL - 2R were increased and in patients with acute hepatitis, chronic hepatitis, liver cirrhosis and liver cancer in comparison with normal controls (P<0. 01); There was a positive correlation between NO and sIL- 2R. Conclusion:Serum NO and sIL-2R had important roles in liver injury, it may be study immunology function and level that liver cells were damaged in patients with liver disease to detected serum NO and sIL- 2R, and it is helpful for diagnosing and treating liver disease earlier.