VCAM-1、TNF-α、IL-6在妊娠期高血压疾病发病中的作用

The study on VCAM-1、TNF-α、IL-6 in the pathogenesis of hypertension disorder complicating pregnancy

目的 探讨外周血清细胞粘附分子 - 1 (VCAM - 1 )、肿瘤坏死因子 -α (TNF -α)、白细胞介素- 6 (IL - 6 )在妊娠期高血压疾病 (HDCP)发病中的作用。方法 采用ELISA测定 6 0例HDCP孕妇 (孕妇期高血压 1 8例、轻度子痫前期 2 2例、重度子痫前期 2 0例 )和 30例正常孕妇血清VCAM - 1、TNF -α、IL - 6水平。结果 ①轻度和重度子痫前期组血清VCAM - 1、TNF -α和IL - 6水平显著高于对照组 (P <0 0 1 ,P <0 0 1 ;P<0 0 1 ,P <0 0 1 ;P <0 0 5 ,P <0 0 1 ) ;②轻度和重度子痫前期组血清VCAM - 1、TNF -α、IL - 6水平呈高度正相关 (r=0 72 ,P <0 0 1 ;r=0 5 9,P <0 0 1 )。结论 VCAM - 1、TNF -α、IL - 6在子痫前期血管内皮损伤发挥重要作用。

Objective To study the roles of vascular cell adhesion molecule-1(VCAM-1),tumor necrosis factor(TNF-α),interleukin-6(IL-6) in the pathogenesis of hypertension disorder complicating pregnancy(HDCP).Methods Sixty women with HDCP(18 gestational hypertension(GH),22 mild preeclampsia(MP),20 severe preeclampsia(SP) and 30 normal pregnant women were studied.Sera VCAM-1,TNF-α and IL-6 were measured by ELISA.Results ①Sera VCAM-1,TNF-α and IL-6 in MP and SP groups were significantly higher than that normal group.② In MP and SP groups sera VCAM-1 was correlate with TNF-α(r=0 72, P <0 01) and IL-6(r=0 59, P <0 01).Conclusions VCAM-1,TNF-α and IL-6 may play important roles in the process of vascular endothelium damages in preeclampsia.