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The Lipid-regulating Effects of Atorvastatin on Type 2 Elder Diabetes Patients with Hyperlipidemia 被引量:1

The Lipid-regulating Effects of Atorvastatin on Type 2 Elder Diabetes Patients with Hyperlipidemia
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摘要 To investigate the effect of atorvastatin on lipid metabolism in type 2 elder diabetes patients with hyperlipidemia, 26 patients with type 2 elder diabetes complicated with hyperlipidemia were treated with atorvastatin (10 mg/d) for 8 weeks. The serum triglyceride (TG), high density protein cholesterol (HDL-C) and low density protein cholesterol (LDL-C) were measured before and after the treatment. Meanwhile, the non-denaturing polyacrylamide gradient gel electrophoresis was used for detection of small-sized LDL(SLDL). Our results showed that TG dropped from 4.88±0.72 mmol/L to 2.65±0.32 mmol/L; HDL-C was increased from 0.85±0.31 mmol/L to 1.28±0.29 mmol/L; LDL-C was declined from 3.71±2.98 mmol/L to 2.10±1.22 mmol/L, sLDL-A was increased from (42.49±8.1)% to (53.27±7.5) %; LDL-B was decreased from (57.91±8.1) % to (46.73±7.5 %) (P<0.05). The level of blood glucose was not changed at the end of 8th week. It is concluded that atorvastatin has satisfactory lipid-regulating effects on type 2 elder diabetes patients with hyperlipidemia. To investigate the effect of atorvastatin on lipid metabolism in type 2 elder diabetes patients with hyperlipidemia, 26 patients with type 2 elder diabetes complicated with hyperlipidemia were treated with atorvastatin (10 mg/d) for 8 weeks. The serum triglyceride (TG), high density protein cholesterol (HDL-C) and low density protein cholesterol (LDL-C) were measured before and after the treatment. Meanwhile, the non-denaturing polyacrylamide gradient gel electrophoresis was used for detection of small-sized LDL(SLDL). Our results showed that TG dropped from 4.88±0.72 mmol/L to 2.65±0.32 mmol/L; HDL-C was increased from 0.85±0.31 mmol/L to 1.28±0.29 mmol/L; LDL-C was declined from 3.71±2.98 mmol/L to 2.10±1.22 mmol/L, sLDL-A was increased from (42.49±8.1)% to (53.27±7.5) %; LDL-B was decreased from (57.91±8.1) % to (46.73±7.5 %) (P<0.05). The level of blood glucose was not changed at the end of 8th week. It is concluded that atorvastatin has satisfactory lipid-regulating effects on type 2 elder diabetes patients with hyperlipidemia.
出处 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2004年第2期138-139,共2页 华中科技大学学报(医学英德文版)
关键词 Atorvastatin diabetes hyperlipidemia Atorvastatin diabetes hyperlipidemia
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参考文献4

  • 1Ashida,Y,Takagi,A,Ikeda,Y.Improved method for non-denaturing polyacrylamide gadient gel electrophoresis for detection of small-sized LDL produced during postprandial hypertriglyceridaemia[].Scandinavian Journal of Clinical and Laboratory Investigation.1999
  • 2.Cost effectiveness analysis of improved blood pressure control in hypertensive patients with type 2 diabetes: UKPDS 40[].British Medical Journal.1998
  • 3Kanters S D,Algra A,de Braint T W et al.Intensive lipidlowering strategy in patients with diabetes mellitus[].Diabetic Medicine.1999
  • 4Davidson M H,Nawrocki J,Weiss S R et al.Effectiveness of atorvastatin for reducing low-density lipoprotein cholesterol to National Cholesterol Education Program Treatment goals[].The American Journal of Cardiology.1997

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