液基细胞学检查与宫颈巴氏涂片的比较

Comparing the Conventional Papanicolaou Smear Test with liquid-based Cytology

目的 :探讨 Thinprep液基细胞学检查用于宫颈癌筛查与宫颈巴氏涂片相比的优越性。方法 :将门诊以宫颈疾病就诊的病人随机分为观察组和对照组 ,观察组 2 5 72例 ,用Thinprep液基细胞学检查初筛 ,对照组 1 2 0 8例 ,用宫颈巴氏涂片初筛。结果 :Thinprep液基细胞学的 L SIL以上病变检出率比宫颈巴氏涂片增加了 81 .5 7% ,L SIL、 HSIL的检出率分别增加了 75 .1 3%、1 1 0 .86%。液基细胞学、宫颈巴氏涂片与病理学检查诊断符合率分别为 84.69%、61 .33%。结论 :液基细胞学检查是细胞学领域的重大进步 。

Objective:To explain the superiority of liquid-based cytology(Thinprep Pap Test) for cervical carcinoma screening in comparison with the conventional Papanicolaou smear. Methods:From October 2002 to August 2003, we randomly divided the out-patients of precancerous lesions of uterine cervix into two groups:observing group and control group. 2572 cases of observing group received the screening test by liquid-based cytology, and 1208 cases of control group were given the same test by the conventional Pap smear. Results:The use of ThinPrep for cervicovaginal cytology produced a 81.57% increase in the detection of low-grade squamous intraepithelial lesions and higher diagnoses. Detection of low-grade squamous intraepithelial lesions and high-grade squamous intraepithelial lesions increased by 75.13%, 110.86% respectively. The coincidence rate of diagnosis with liquid-based cytology and biopsy was 84.69%, while that of conventional Pap smear and biopsy was 61.33%. Conclusion:Liquid-based cytology is an important innovation in the field of cytology, which will increase the diagnostic accuracy of cytology greatly.