血清CA125、CEA、AFP联合检测在卵巢肿瘤诊断中的价值

Diagnostic Value of Determination of Serum CA125,CEA and AFP in Patients with Ovarian Tumors

目的 :探讨血清 CA1 2 5、CEA和 AFP联合检测在卵巢肿瘤诊断中的价值。方法 :采用酶联免疫分析法 ( EL ISA)对卵巢恶性肿瘤、良性肿瘤及子宫内膜异位症患者血清CA1 2 5、CEA及 AFP含量进行检测。结果 :卵巢恶性肿瘤患者 CA1 2 5含量明显高于对照组、卵巢良性肿瘤及交界性瘤 ( P<0 .0 1 ) ;子宫内膜异位症及盆腔炎患者 CA1 2 5含量高于对照组及卵巢良性肿瘤 ( P<0 .0 5 ) ;卵巢恶性肿瘤患者 CA1 2 5含量高于子宫内膜异位症 ( P<0 .0 5 )。结论 :单项检测 CA1 2 5对卵巢上皮性癌诊断性能最佳 ,对子宫内膜异位症也有较理想的诊断价值 ,CA1 2 5、CEA及 AFP联合检测对卵巢恶性肿瘤的诊断无明显价值 。

Objective:To study the diagnostic value of combined measurement of the cancer antigen 125 (CA125), CEA and AFP in patients with ovarian tumors. Methods:ELISA was used to measure the levels of serum CA125,CEA and AFP in patients with benign ovarian tumor, malignant ovarian tumor and endometriosis as well as normal controls. Results:Serum CA125 level was significantly higher in patients with malignant ovarian tumor than that in those with benign or borderline ovarian tumor and in control group(P<0.01). Serum CA125 level was higher in patients with endometriosis and pelvic infection than that in those with benign ovarian tumor and in control group(P<0.05).It was higher in patients with malignant ovarian tumor than that in those with endometriosis(P<0.05). Conclusion:The single detection of CA125 may be the best method of diagnosing ovarian epithelioma, and the detection of AFP has greater value in diagnosing malignant germ cell tumor.