实时声学造影和全功能声学密度定量技术评价冠心病患者心肌血流量的临床研究

Assessment of myocardial blood flow in patients with coronary artery disease using global acoustic density technique and real-time contrast echocardiography

目的 探讨实时声学造影以及全功能声学密度定量技术 (globalacousticdensity ,GAD)评价冠心病患者心肌血流量 (myocardialbloodflow ,MBF)的临床应用价值。 方法 对 18例冠心病患者行SonoVue经静脉声学造影检查 ,应用GAD定量其心肌血流量情况。结果 18例患者均顺利完成SonoVue经静脉声学造影检查。GAD定量分析 :冠心病患者病变不明显冠状动脉供应节段的MBF明显高于狭窄冠状动脉供应的节段 [(61.94±3 1.0 1)dB2 /s对 (2 2 .0 9± 18.12 )dB2 /s ,P <0 .0 1] ;经皮冠状动脉成形术 +支架植入术重建血管相关节段的MBF仍低于病变不明显冠状动脉供应的节段 [(2 8.84± 2 3 .94)dB2 /s对 (66.12± 3 3 .46)dB2 /s ,P <0 .0 1]。结论 实时声学造影及GAD能够定量分析冠心病患者心肌血流量情况。

Objective To investigate the clinical value of quantitative assessment of myocardial blood flow(MBF) in patients with coronary artery disease(CAD)using real time contrast echocardiography and global acoustic density technique(GAD).Methods As contrast echocardiography performed in 18 patients with CAD using SonoVue (Bracco) intravenously,apical four chamber and two chamber views of left ventricle were obtained.MBF was assessed quantitatively using GAD.Results All the 18 patients underwent real time contrast echocardiography successfully.MBF was significantly higher in segments supplied by normal coronary arteries than those supplied by narrowed ones [( 61.94 ± 31.01 ) dB 2/s vs ( 22.09 ± 18.12 ) dB 2/s,P< 0.01 ] among the patients with CAD.MBF was still lower in segments supplied by coronary arteries after PTCA and stenting than that in normal ones [( 28.84 ± 23.94 ) dB 2/s vs ( 66.12 ± 33.46 ) dB 2/s,P< 0.01 ].Conclusions Real time contrast echocardiography and GAD can evaluate MBF in patients with CAD correctly and directly.