赠卵体外受精-胚胎移植在卵巢早衰和非早衰受者中的应用

The application of oocyte donation in in vitro fertilization-embryo transfer for recipients with and without premature ovarian failure

目的 探讨赠卵体外受精 胚胎移植 (IVF ET)中子宫内膜同步化激素治疗及比较卵巢早衰 (POF)和非POF受者的赠卵IVF ET效果。 方法 回顾性分析 5 0例赠卵IVF ET患者的 6 0个IVF周期和 73个ET周期。按赠卵指征分为POF组19例、2 3个周期和非POF组 31例、37个周期 ,进行t和 χ2 检验统计学分析。 结果 赠卵IVF ET的妊娠率为 4 8% (2 4 / 5 0 )和刺激周期为 4 3% (2 6 / 6 0 ) ;POF组妊娠率高于非POF组 ,但无显著性差异 (P >0 .0 5 )。子宫内膜同步化方法促性腺激素释放激素激动剂 /外源雌三醇 /黄体酮 (GEEP)方案组妊娠率明显高于后两者的 (EEP)组 (P <0 .0 5 )。 结论 卵巢早衰患者赠卵IVF ET妊娠率较高。子宫内膜同步化方法因人而异 。

Objective: To evaluate the methods of hormone therapy for establishing endometrium synchronous with the embryo in an oocyte donation in in vitro fertilization embryo transfer (IVF ET) program and to compare the effectiveness of oocyte donation in IVF ET in patients with premature ovarian failure (POF) versus those non POF Methods: Retrospective clinical study of 60 oocyte donation IVF ET cycles and 73 ET cycles was performed in 19 POF patients (23 cycles) and 31 non POF patients (37 cycles). T test and chi square test were used for statistical analysis. Results: The clinical pregnancy rates (PR) per patient and per cycle in oocyte donation IVF ET were 48% (24/50) and 43% (26/60), respectively. No significant difference was found between POF and non POF groups despite recognizable difference in recipient age. The PR per transfer was significantly higher in the regimen of gonadotropin releasing hormone agonist combined with exogenous estradiol and progesterone (GEEP) than that of exogenous estradiol and progesterone (EEP) only for synchronizing endometrium in eugonadal patients ( P <0.05) Conclusion: Oocyte donation in IVF ET in POF patients has a slightly higher PR. GEEP regimen for synchronizing endometrium is better than EEP in eugonadal patients.