γ射线与噪声对耳蜗损伤的协同作用

The synergetic effect of r-irradiation and noise on damage of cochlear

本研究采用听神经埋藏电极和扫描电镜技术,分别记录和观察了在舰艇主机噪声(105±2dBA,持续30min),γ射线(80Gy,一次照射)及γ射线与噪声联合(先照射后噪声暴露)暴露条件下,豚鼠的听力损失和耳蜗毛细胞的病理变化.结果表明,联合暴露组的听力损失明显大于照射组与噪声组听力损失的总和;其耳蜗毛细胞损伤也比照射与噪声组严重.表明γ射线与噪声对豚鼠耳蜗损伤产生了协同作用,其γ射线可能决定了损伤的性质,噪声促进了损伤的发展.

Under the action of noise exposure (105 ± 2 dBA, duration of 30 min), γ-irradiation (single irradiation of 80 Gy) and combined exposure of them (γ-irradiation followed by noise), the hearing loss and pathological change of hair cells of the cochlea in guinea pigs are respectively measured and examined by means of chronic induction of ecochg via canalis facialis and scanning electron microscope in this study. The results show that the hearing loss for combined exposure group exceeded the summation loss caused by irradiation and noise alone, and the damage of outer hair cells in organ of Corti was severer than that of irradiation or noise exposed group. It indicates that the synergetic effect of γ-irradiation and noise exposure occurs on cochlear damage in guinea pigs. In the combined exposure the curve shape of threshold shifts is similar to γ-irradiation alone, but the amount of threshold shifts, is considerably more than that of γ-irradiation. It shows that the damage property of the cochlear may mainly depend on the γ-irradiation, and the noise exposure is only an accelerating agent for the synergetic effects on the damage of the cochlear.