X线照射弓状核损伤雄性大鼠头部对神经内分泌的影响

EFFECT OF HEAD IRRADIATION WITH X-RAYS ON NEUROENDOCRINE IN MALE RATS OF HYPOTHALAMIC ARCUATE NUCLEUS LESIONS

已知初生期大鼠注射谷氨酸钠(MSG)可引起下丘脑弓状核严重损毁。本研究表明,雄性大鼠出生后2d及4d,腹腔注射MSG(4mg/g体重),成年后神经内分泌系统功能发生明显改变。用MSG处理雄性大鼠经10Gy X线头部照射后48h,与非照射MSG处理组比较,血清LH、FSH、TSH和GH水平以及血清和尿睾丸酮含量趋于降低;而血清PRL水平趋于增高,垂体和睾丸cAMP含量变化不明显。提示,MSG损毁弓状核雄性大鼠神经内分泌系统调节功能失常,经10 GyX线头部照射后48h,不能出现正常大鼠头部照射后下丘脑-垂体系统功能增强的效应。

It has been demonstrated that neonatal administration of monosodiumglutamine (MSG) results in clearly defined lesions of the hypothalamic arcuate nucleus.The present study showed that neuroendocrine function cbanged significantly in adul-thood when boby rats were injected with MSG (4 mg/g BW, ip) 2 and 4 days aftertheir birth. The serum LH, FSH, TSH and GH and serum and urine testosterone (TS)levels and pituitary cAMP content were lower in MSG treated rats than those of in-tact rats, but the serum PRL level increased significantly and the testicular cAMP co-ntent didn't change. Fourty eight hours after head irradiation with 10 Gy X-rays inthe male rats treated with MSG, the serum LH, FSH, TSH and GH and serum andurine TS levels tended to decrease, while the serum PRL level tended to increase andthe pituitary and testicular cAMP contents didn't change. The results suggest that thefunctional irregulation of neuroendocrine system in MSG treated rats with extensivelesions of hypothalamic arcuate nucleus were not so significant as those of intact ratsin response to irradiation.