2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的制备

Synthesis of 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine Hydrochloride

以2,3,5-三甲基吡啶经N-氧化、硝化、甲氧基取代、乙酰化、水解、卤代及成盐等反应制得奥美拉唑中间体2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐,总收率63.6%。原料易得,反应条件温和,操作简便。

The title compound was synthesized from 2,3,5-trimethylpyridine by N-oxidation, nitration, methoxylation,acylation and hydrolysis to give 2-hydroxymethyl-4-methoxy-3,5-dimethylpyridine which was chlorinated by SOCl2 andfollowed by salification in an overall yield of 63.6%.