米氮平和阿米替林维持治疗抑郁症患者的疗效和依从性比较

Mirtazapine and Amitriptyline in the Maintenance Treatment of Depressed Patients:Comparison of Efficacy and Compliance

目的 :比较抑郁症患者用米氮平和阿米替林维持治疗的疗效和依从性。方法 :60例门诊抑郁症患者随机分为服用米氮平组和阿米替林组 ,均治疗 5 2周 ,用汉密尔顿抑郁量表 (HAMD)等在治疗前及治疗后 12、 5 2周末比较两组的疗效和依从性。结果 :12周后 ,两组治疗前后比较均有非常显著性的疗效 (P<0 0 1) ,但两组间比较差异无显著性 (P >0 0 5 ) ;5 2周后 ,米氮平组具有非常显著性的疗效 (P <0 0 1) ,阿米替林组具有显著性的疗效 (P <0 0 5 ) ,两组之间比较差异具显著性 (P <0 0 5 )。米氮平组副反应发生率远低于阿米替林组。结论 :抑郁症患者对米氮平依从性高主要是因疗效好和副反应轻。

Objective:To assess the compliance and efficacy of mirtazapine or armitriptyline in the maintance treatment of depression. Methods:60 depressive outpatients were randomly allocated to two groups treated with mirtazapine or armitriptyline for 52 weeks. Before treatment and at the ends of 12 weeks and 52 weeks of treatment, to assess the efficacy using the Hamiltion Depression Scale (HAMD)and Clinical Global Impression(CGI),to assess the compliance and the adverse-effects using the Hamilton Depression Scale (HAMD)and Clinical Global Impression(CGI),to assess the compliance and the adverse-effects using Treatment Emergent Symptom Scale (TESS).Results:After 12 weeks, significant improvement was observed respectively in the two groups(P<0.01),but no difference in efficacy was observed between the two groups. After 52 weeks, very significant efficacy was observed in the mirtazapinetreated group(P<0.01),while just significant efficacy was observed in the armitriptyline-treated group(P<0.05),and difference was observed between the two groups(P<0.05).The rate of adverse-effects was much lower in mirtazapine-treated group than armitriptyline-treated group.Conclusions:Compliance of mirtazapine was better because of its good efficiency and less adverse-effects.