高度近视与原发性开角型青光眼(英文)

Relationship between high myopia and primary open-angle glaucoma

目的:从流行病学、临床特征及诊断、遗传学说及机制等方面对高度近视与原发性开角型青光眼的关系及研究进展进行综述。方法:仔细分析了28篇原文,总结出高度近视与原发性开角型青光眼的可能机理。结果:高度近视与原发性开角型青光眼密切相关,其可能的机制有:①升压基因学说。②胶原基因学说。结论:高度近视与原发性开角型青光眼密切相关,根据TIGR基因理论和胶原基因理论,高度近视与原发性开角型青光眼都与TIGR基因突变和胶原疾病有关。

AIM: To review the relationship between high myopia (HM) and primary open angle glaucoma (POAG) from the aspects of epidemiological features, clinic features, diagnosis, as well as genetic and molecular mechanism.· METHODS: Twenty-eight original articles related to this issue were selected. These articles were carefully reviewed to find out the possible mechanism of the relationship between HM and POAG.· RESULTS: HM is a genetically-associated disease and is closely related with POAG. According to the TIGR gene theory and the collagen gene theory, HM and POAG are both associated with the mutations of TIGR and collagenous lesions.· CONCLUSIONS: HM and POAG are closely related to each other in that their mechanisms are both related to hypertension gene and collagen gene.·