阿昔洛韦治疗基本型单纯疱疹病毒性角膜炎两种用药途径的比较

Two ways of using aciclovir in treatment of herpes simplex keratitis

目的:评价阿昔洛韦眼液及口服片剂在治疗单纯疱疹病毒性角膜炎中的疗效。方法:采用随机、单盲、平行对照的方法选择60例单纯疱疹病毒性角膜炎患者,30例用阿昔洛韦眼液,为A组:男19例,女11例,年龄7～61(平均33.9)岁;30例用阿昔洛韦口服片剂,为B组:男13例,女17例,年龄10～65(平均38.2)岁。A组用1g/L阿昔洛韦眼液,点眼5～8次/d,2滴/次。基本痊愈后减为3次/d,维持8wk。B组用阿昔洛韦口服片,0.2g5次/d,基本痊愈后减为2次,0.4g/次,维持8wk。评价其症状体征的改善率、总有效率和不良反应。结果:2组治疗7d时总有效率为30%和87%,P <0.01;治疗14d后A组总有效率为90%,B组为100%,P >0.05。不良反应轻微。结论:阿昔洛韦是一种有效、安全的治疗病毒性角膜炎的药物。局部及全身治疗,疗效明显优于其它药物,且疗程短。

AIM: To evaluate the effect of treating herpes simplx keratitis with two methods using aciclovir.· METHODS: Sixty patients were randomly divided into two groups: thirty patients in group A using aciclovir eye drop and 30 patients in group B using aciclovir tablets.· RESULTS: After 7-day treatment, the efficacy rate was 30% in group A and 90% in group B (P <0.01). After 14d the total efficacy rate was 87% in group A and 100% in group B (0.01<P <0.05). No serious complication occurred.· CONCLUSION: Aciclovir is effective and safe in the treatment of herpes simplx keratitis. Combindd with eye drop and tablets administration the efficacy is superior to that of other medicine with shorter period of treatment.·