摘要
聚苯乙烯负载硒溴与炔基锂反应合成聚苯乙烯负载炔基硒醚,再与二环己基硼烷反应制得聚苯乙烯负载顺式烯基硒醚;此负载型烯基硒醚在NiCl2(PPh3)2存在下与格氏试剂发生偶联反应,提供了一种有效的(Z)-1,2-二取代乙烯的固相有机合成方法.
Treatment of polystyrene-supported selenium ,bromide with lithium acetylides afforded polystyrene-supported selenoacetylene, which reacted with dicyclohexylborane giving a way for stereoselective synthesis of polymer-supported (Z)- vinylic selenides. Cross-coupling reaction of polymer-supported (Z)- vinylic selenides with Grignard reagents in the presence of NiCl_2(PPh_3)_2 as catalyzed yielded (Z)-1,2-disubstituted ethenes on solid-phase.
出处
《江西师范大学学报（自然科学版）》
CAS
2004年第2期126-128,150,共4页
Journal of Jiangxi Normal University(Natural Science Edition)
基金
江西省自然科学基金(001109)
江西师范大学青年成长基金资助项目.
关键词
固相有机合成
聚合物试剂
炔基硒醚
烯基硒醚
偶联反应
(z)-1
2-二取代乙烯
组合化学
solid-phase organic synthesis
polymer-supported reagent
alkynyl selenide
vinylic selenides
cross-coupling reaction
(Z)-1,2-disubstituted ethenes
