血液系分子标志物检测在DIC前期诊断中的应用

APPLICATION OF MONOMOLECULAR LABEL DETECTON OF BLOOD IN THE DIAGNOSIS OF DIC PROTOPHASE

选择DIC发生率最高的造血系恶性肿瘤51例(急性白血病16例、慢性白血病5例、恶性淋巴瘤26例、多发性骨髓瘤4例),不同时期收集血标本205份,以FDP为主要项目,探讨FDP与血液系分子标志物:TAT、PIC、D—dimer、TM各位在DPC前期诊断中的应用和它们之间的关系。结果提示:FDP是反映凝血、纤溶两方面活化程度的指标,但TAT、PIC、D-dimer较FDP更敏感地反映凝血、纤溶活性化,可以作为DIC前期诊断的指标。此外,作为血管内皮细胞损伤指标TM的增高,可能与白细胞中蛋白酶的分解作用有关。

Fiftyone cases with the highest incidence rate of hematopoietic system malignant tumor (acute leukemia 16 cases, chronic leukemia 5 cases, malignant lymphoma 26 cases, myeloma 4 cases) were seleeted and 205 share blood specimen were collected in different periods to determine the FDP. The clinical application value of FDP, coagulation and fibrinolytic molecular label and the relationship among them were studied.Conclusion was:FDP was the in dex reflecting the activation of ccagulation and (?)ibrinolytic, but TAT, PIC, D-dimer were more sensitive than FDP, so they might be the index for the diagnosis of DIC protophase.Above all, the increased TM might have relation to the decomposition of protease.