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肿瘤转移相关分子——骨桥蛋白 被引量：1

Osteopontin:tumor metastasis-associated protein
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摘要 机体内有多种细胞可以分泌一种磷酸化蛋白———骨桥蛋白 (OPN) ,依靠整合素的辅助 ,OPN在不同的生理和病理机制中起着重要的作用。很多种肿瘤组织都可以表达OPN。近来的一些研究表明 ,肿瘤细胞表达的OPN与肿瘤的侵袭、转移过程关系密切。 Osteopontin (OPN) is a multifunctional phosphoprotein secreted by various cells.OPN serves in both cell attachment and cell signaling by interacting with integrins in various pathological conditions.OPN expression has been demonstrated in a variety of human carcinomas.The recent studies showed that OPN expressed by tumor cells was associated with the motile and invasive behaviors of tumor cells,suggesting that OPN might contribute to invasion and metastasis of tumors.
作者 宋建 张东生 郑杰
机构地区 东南大学基础医学院病理学与病理生理学系
出处 《东南大学学报（医学版）》 CAS 2004年第3期206-210,共5页 Journal of Southeast University(Medical Science Edition)
基金 江苏省科委社会发展基金资助项目 (BS980 31 )
关键词 肿瘤转移 骨桥蛋白 分子结构 生物学特点 细胞免疫反应 osteopontin tumor metastases
分类号 R730.6 [医药卫生—肿瘤]
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参考文献18

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同被引文献10

  • 1BEER T M,MYRTHUE A.Calcitriol in cancer treatment:from the lab to the clinic[J].Mol Cancer Ther,2004,3(3):373-381.
  • 2LOU Y R,QIAOI S,TALONPOIKA R,et al.The role of vitamin D3 metabolism in prostate cancer[J].J Steroid Biochem Mol Biol,2004,92(4):317-325.
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  • 8van den BEMD G J,JHAMAI M,STAAL A,et al.A central dinucleotide within vitamin D response elements modulates DNA binding and transactivation by the vitamin D receptor in cellular response to natural and synthetic ligands[J].J Biol Chem,2002,277(17):14539-14546.
  • 9CAMPBELL F C,XU H,EL-TANANI M,et al.The Yin and Yang of vitamin D receptor(VDR) signaling in neoplastic progression:operational networks and tissue-specific growth control[J].Biochem Pharmacol,2010,79(1):1-9.
  • 10TRUMP D L,POTTER D M,MUINDI J,et al.Phase II trial of high-dose,intermittent calcitriol(1,25 dihydroxyvitamin D3) and dexamethasone in androgen-independent prostate cancer[J].Cancer,2006,106(10):2136-2142.

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东南大学学报（医学版）
2004年 第3期

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