超细β-磷酸三钙/聚-L-乳酸复合材料的制备与骨折内固定器的加工

Preparation of ultrafine β-tricalcium phosphate/Poly(L-lactide) composites and processing of internal fracture fixation nails

目的 :制备分散性良好的超细 β 磷酸三钙 ( β TCP) 聚 L 乳酸 (PLLA)复合材料及新型可吸收骨折内固定器。 方法 :通过研磨方法制备 β TCP超细粒子 ,用一缩二乙二醇作分散剂研磨 β TCP后 ,再将 β TCP与PLLA超声混合 ,制得复合材料 ,经注塑加工制成可吸收骨钉 ,并采用扫描电镜等方法进行表征。结果与结论 :用一缩二乙二醇作分散剂研磨 β TCP后再经超声混合 ,可以使 β TCP超细粒子在复合材料中分散均匀 ,粒子大小仅为 3 0 0nm左右 ,β TCP与PLLA基体之间结合良好。超细 β TCP PLLA复合材料可加工成可吸收骨钉 ,弯曲强度达到 10 0MPa左右 。

Objective To prepare a new type of bioabsorbable nails for internal fracture fixation which were processed with the composites of ultrafine β?tricalcium phosphate(β?TCP)/poly(L-lactide)(PLLA) with a uniform dispersion of the β?TCP particles.Methods In this paper,ultrafine β?TCP was ground into fine particles,and composites of ultrafine β?TCP/PLLA were obtained by different mixing methods, SEM and XRD were used to characterize the particles.Bioabsorbable nails for internal fracture fixation were processed with the composites of ultrafine β?TCP/ PLLA with a uniform dispersion of the β?TCP particles.The dispersion of ultrafine β?TCP in the matrix was observed by SEM.Result The results showed that ultrafine β?TCP particles dispersed uniformly in the matrix of PLLA while using diethylene glycol as dispersant during grinding,and the diameters of particles varied in the range of 200 to 400?nm.The mechanical properties of the bioabsorbable nails were measured by bending method.The bending strength of the nails reached about 100?MPa.Conclusion The newly invented internal fracture fixation nails perfectly meet clinical demands.