皮肤狼疮带试验与临床分析

Clinical Analysis of the Lupus Band Test

目的 探讨狼疮带试验 (LBT)的临床意义。方法 用直接免疫荧光技术 (DIF)检测SLE患者外观正常皮肤或皮损的真、表皮交界处 (BMZ)免疫球蛋白或补体的沉积 ,并同时与SLE主要临床症状进行统计分析。结果 SLE患者 72例 ,LBT阳性率为 75 .0 % ;免疫复合物沉积种类以IgM阳性率最高 ( 79.6% ) ,C3 其次 ( 72 .2 % ) ,IgG ( 61.1% )位于第 3 ,IgA( 16.7% )最低。免疫复合物常见结合成份为IgM加C3 。免疫复合物沉积种类与疾病严重程度有一定关系。结论 LBT对SLE的诊断有较高的特异性 ,与临床一些主要症状的发生有一定相关性。但LBT用于临床诊断 ,应结合临床症状及实验室多项实验指标综合评估。

Objective To discuss the clinical significance of lupus band test (LBT).Methods By using direct immuneofluoresence(DTF),we detected the presence of immunoglobulin and Complenent C_3,which is deposited on the Basement Membrane zone (BMZ) of lesions or normal appearance skin,and make statistical analysis with the result and major signs of SLE.ResultsThe total positive rate of LBT in 72 cases of SLE is 75.0%.The deposit pattern is IgM 79.6%,C_37.2%,IgG 61.1% respectively,and IgA deposit is the lowest 16.7%.The most common immune complex is IgM and C_3 deposit,it was also implied the immunoglobulin deposit pattern is correlated with the severity of SLE.Conclusion LBT is specific for the diagnosis of SLE and is a related factor to its prognosis.LBT can be utilized for SLE diagnosis.More important is the signs and laboratory results when diagnosis was made.