生麦散对失血性休克家兔血浆内皮素和肿瘤坏死因子等的影响

Effect of Shengmai Powder on endothelin and tumor necrosis factor in hemorrhagic shock in rabbits

目的 :探讨生麦散 (SMS)对失血性休克的治疗作用。方法 :观察生麦散对失血性休克家兔休克前后血浆内皮素(ET)、肿瘤坏死因子 (TNF)、β 内啡肽 (β EP)、一氧化氮 (NO)含量及一氧化氮合酶 (NOS)活性的影响。 结果 :生麦散能明显降低失血性休克家兔血浆ET、TNF、β EP、NO水平及NOS活力的升高 (P <0 .0 5 )。 结论 :生麦散可通过调节ET、TNF、β EP。

AIM:To investigate the role of Shengmai Powder (Radix Ginseng, Radix Ophiopogonis and Fructus schisandrae) (SMP) in treatmen of hemorrhagic shock in rabbits. METHODS: The concentrations of endothelin (ET), tumor necrosis factor (TNF), β endorphin (β EP) and nitric oxide (NO), the activity of nitric oxide synthase (NOS) in plasma were respectively tested by different biochemical assays in hemorrhagic shock in rabbits. RESULTS: SMP could obviously decrease the ET,TNF,NO level and NOS activity ( P <0.05) of plasma in hemorrhagic shock in rabbits. CONCLUSIONS: SMP has higher treatment value on hemorrhagic shock by improving the levels of ET,TNF,β EP and NO in plasma.