摘要
以要素膳做营养支持的S180小鼠40只,完全随机法分成用药组(次黄嘌呤核苷50mg·kg^(-1)/d)和对照组(等量安慰剂),观察以下各指标并倣统计学处理:荷瘤生存期限;肿瘤生长速度;血乳酸值及乳酸/丙酮酸比值;血氨基酸谱分析;瘤细胞匀浆中c-AMP值以及c-AMP/c-GMP比值等。结果提示次黄嘌呤核苷能提高营养支持的荷瘤机体对肿瘤竞争摄取营养的能力,从营养支持调节的角度产生抑瘤作用。
Fourty mice with S 180 sarcoma under nutrition support of elemental diet devided a randomly into two groups: experimental group: inosine 50 mg·kg^(-1)/d in elemental diet; control group: equivalent quantity of starch in elemental diet. The obsevation and the statistics for the survival time of tumor bearing animals, speed of tumor growth, serum lactic acid and the ratio between lactic acid puryate, serum amino acid levels, c-AMP and the ratio of c-AMP/c-GMP in tumor cells suggested that inosine plays a role in inhibiting the nutrients up-take of S180 sarcoma cells through the adjustment of nutrition support for tumor bearing animals.
出处
《北京医学》
CAS
北大核心
1992年第5期282-283,共2页
Beijing Medical Journal
