肾病综合症患者凝血及纤溶指标变化的意义

The meaning of diversified parameters of coagulation and fibrolysis in patients with nephritic syndrome

目的 探讨肾病综合征与凝血及纤溶指标的关系。方法 用SysmexCA - 1 50 0全自动血凝仪对 30例正常对照组 ,65例肾病综合征组的凝血酶原 (PT)、活化部分凝血活酶时间 (APTT)、纤维蛋白原 (Fbg)、D -二聚体 (D -D)进行检测并分组比较。结果 肾病综合征组与正常对照组比较PT缩短 (P >0 .0 5) ,无统计学意义 ,APTT明显缩短、Fbg与D -D明显升高 (p <0 .0 1 ) ,均有统计学意义。结论 肾病综合征病人存在高凝状态及纤溶亢进 ,测定凝血及纤溶系统的一些项目可了解病情并有利于治疗。

Obsjective to investigate the relationship of the nephritic syndrome and the parameters of coagulation and fibrolysis. Methods Prothrombin time(PT), Activated partial thromboplastin time(APTT), Fibrinogen(Fbg) and D dimer(D-D) were determined by Sysmex CA-1500 automatic coagulometer in 30 healthy volunteers and 65 patients.Results PT in patients with nephritic syndrome were not different statistically when compared with those of healthy controls(p>0.05), but APTT was decreased, Fbg and D-D increased significantly in patients (p<0.01). Conclusions The state of hypercoagulability and hyperfibrinolysis exist in the patients with nephritic syndrome.It is advantageous to find out the state of the illness for the treatment by mensurating some parameters of coagulation an fibrolysis .