腹水超滤回输后腔内灌注榄香烯乳治疗癌性腹水疗效观察

The Effect of Carcinomatous Hydroperitonia by Instillating β-elemene Milk into Abdominal Cavity after Hydroperitonia Ultrafiltratio Refusion

目的 观察腹水超滤回输腹腔后腔内灌注榄香烯乳治疗癌性腹水的疗效。方法 将72例恶性肿瘤并发大量癌性腹水的患者随机分为治疗组和对照组(各36例),治疗组用AR-I型自体腹水超滤回输治疗仪将腹水超滤回输腹腔后腔内灌注榄香烯乳,对照组于反复常规腹腔穿刺放液后腹腔内灌注榄香烯乳治疗,比较两组疗效及治疗前后腹水蛋白、血浆白蛋白的含量,尿量和Karnofsky评分变化,观察不良反应。结果 治疗组完全缓解(CR)9例,部分缓解(PR)22例,无效(NC)5例,有效率86.1%;对照组CR 4例,PR 20例,NC 12例,有效率66.7%。两组疗效比较有显著性差异,治疗组治疗后腹水蛋白、血浆白蛋白均有明显升高,尿量增加,Karnofsky标准评分分值明显提高,与对照组比较均有显著性差异。结论 腹水超滤回输腹腔后腔内灌注榄香烯乳治疗癌性腹水有较好的疗效,能明显提高患者的生活质量,省时、省力而安全,无明显不良反应。

Objective To explore the effect of carcinomatous hydroperitonia by instillating β-elemene milk into abdominal cavity after hydroperitonia ultrafiltratio refusion. Methods Seventy-two cases of malignant tumour with carcinomatous hydroperitonia were randomized into the treatment group and the control group, respectively 36 cases. The treatment group was treated with the instrument of hydroperitonia ultrafiltratio refusion (AR-I) by instillating β-elemene milk into abdominal cavity after hydroperitonia ultrafiltratio refusion, the control group after puncturing regularly and repeatedly. Comparing the carcinomatous exudate, the amount of protein of hydroperitonia of therapeutic anteroposterior, plasm albumin, urine, Karnofsky score, observating toxic and side effect. Results The CR, PR, NC and effective rate were 9, 22, 5 (cases) and 86.1% in the treatment group, while 4, 20, 12 (cases) and 66.7% in the control group respectively. The amount of protein of hydroperitonia plasm, albumin, urine, Karnofsky score were enhanced insignificantly in the treatment group as compared with the control group. Conclusion The effect of carcinomatous hydroperitonia by instillating β-elemene milk into abdominal cavity after hydroperitonia ultrafiltratio refusion was better, enhancing evidently the quality of life and saving time and being security, not having side effect.