多原发大肠癌起源机理初步探讨

The Study by Flow Cytometry of the Origin of Multiple Primary Colorectal Carcinomas

本文应用流式细胞仪对7例多原发大肠癌共15个癌瘤细胞DNA含量进行了检测,以探讨多原发大肠癌的起源机制。结果表明,7例多原发大肠癌中有4例多个癌瘤DNA含量相同;3例DNA含量不同。15个癌瘤中有4个为异倍体(26.7％);11个癌瘤为二倍体(73.3％)。这一结果提示:在同一大肠内的多个癌瘤至少在一部分病例中可能来自同一起源,其机理可能是由一原发灶经肠腔内转移所致。而DNA含量不同的病例结果支持肿瘤单独起源假说。

The DNA content in 15 colorectal cancers from 7 patients was measured by flow cytometry on paraffin-embedded specimens to see if this parameter supported common or independent origins for such synchronous and metachonous tumors. In 4 of the 7 cases, the tumors within each colon had identical DNA indices, and in three cases both tumors from the same colon differed with respect to DNA content. Four(26.7%) of 15 tumors were aneuploid. The remaining 11 tumors were diploid. These findings suggest a common origin for the cases who had identical DNA content, it may arise as translumenal metastases from an initial single lesion The others are compatible with multiple origins.