益肝灵保护大鼠肾缺血再灌注损伤的实验研究

The Experimental Investigation of Protective Effects of Yiganling on Renal Ischemia-Reperfusion Injury in Rats

目的 探讨益肝灵对肾缺血再灌注损伤的保护作用。方法 建立肾缺血再灌注模型 ,大鼠右肾切除 ,左侧肾蒂夹闭 4 5min后再灌 6 0min。用益肝灵预防性治疗 ,检测并比较肾组织及血清中MDA及SOD的活性变化。结果 益肝灵能明显抑制缺血再灌所致的血及肾组织中MDA的升高和SOD的活性降低。

Objective To investigate the protective effects of Yiganling renal ischemia-reperfusion injury in rats. Methods Using a rat model with 45 min renal ischemia followed by 60 min reperfusion. Renal tissues and serum levels of MDA and SOD after treatment with Yiganling were detected and compared. Results With renal ischemia and reperfusion, SOD activities declined and MDA content significantly increased and these effects could be partially depressed when Yiganling was infused. Conclusions Yiganling can protect kidney against ischemia-reperfusion injury.