绝经与年龄影响妇女骨质丢失的比较

Relative Contributions of Aging and Menopause to Bone Loss in Chinese Women

以丹麦产^(125)I源单光子骨密度仪测量490例30～78岁汉族妇女的前臂骨密度,骨密度从45岁以后明显下降,70岁组只有30岁组的57.5～61.2％,每年下降1～2％,而绝经前妇女的骨密度随年龄的变化较小,绝经后骨质丢失速度加快.尤以绝经3年内明显。手术绝经使骨质丢失提前发生,但不加重。作者认为绝经比年龄对妇女骨质丢失的影响更大。

The forearm bone mineral content (BMC) were determined by single photon absorptiometry (SPA) in 490 cases of healthy Chinese Han women, aged 30-78, 78 premenopausal and 412 postmenopausal with menopausal years covering from 0.5 to 30. BMC decreased significantly after age 45 or the occurence of menopause (P<0.05),but the different age groups showed no significant difference before age 55 in the 78 premenopausal women (P>0.05). No sooner occured the menopause than bone loss accelerated, and 2.4～10.5% of BMC was lost a year within 3 year which followed by 2～3% annually while the rate in (he period of 10～15 years postmenopausal became less than 1%. The surgical menopause group had the same BMC as the natural menopause group (P>0.05). The incidence of postmenopausal osteoporosis was about 40% among the 412 postmenopausal women. Considering the varied age of menopause and the accelerating bone loss in the early postmeno pausal periods, we suggest that menopause play more important role than aging in the prediction of women 's bone loss.