Galanin协同生长释放素(GHRH)促进生长激素(GH)的释放

Combination of Galanin and Growth Hormone Releasing Hormone (GHRH) Enhances GH Release

Galanin是新发现的促进GH释放的下丘脑激素。已知给正常人反复注射GHRH会导致GH释放的减低。我们研究了6例正常人对重复注射GHRH同时滴注galanin的GH反应。结果表明重复注射GHRH后GH释放明显减低,但在重复注射同时合用galanin则GH释放显著增强。galanin和GHRH联合应用克服了因重复注射GHRH所致的GH反应降低。其机理可能是gatanin抑制下丘脑SRIH的分泌之故。

Galanin is a new hypothalamic hormone which induces GH release. It is well known that in normal subjects repeated administralion of GHRH leads to decrease GH response. We studied the effects of two consecutive GHRH boluses (1.0ug/kg, iv, every 120min) alone or coadminitstered with galanin (15ug/kg, infusion, over 60 min) at the second bolus injection on GH release in 6 healthy volunteers. It was found that the GH release after the second bolus of GHRH alone was significantly lower than that of the first one. whereas, Galanin remarkedly enhanced the GH response to the second GHRH bolus. This result showed that combination of galanin and GHRH reinstated the GH response to the repeated GHRH stimulation in man. The mechanism of this effect might be via an inhibition of somatostatin secretion in hypothalamus.