血清铜锌比值在乳癌复发诊断中的意义

Significance of Copper/Zinc Ratio in Diagnosis for Recurrent Breast Cancer

对40例乳癌术后患者血清铜、锌进行了测定。结果表明,乳癌复发组血清铜升高,锌下降,与未复发组比较均有显著差异(P<0.05)。血清铜锌比值复发组非常显著高于未复发组(P<0.001)。以铜锌比1.54作为截断值,对乳癌复发诊断的灵敏度及特异度分别为69％和85％,诊断指数为0.54。在与血清癌胚抗原(CEA)结合分析时,诊断灵敏度及特异度分别为91％和75％,诊断指数为0.66。提示:血清铜锌比对乳癌复发的诊断具有较好的意义,尤其是在与血清GEA结合诊断时,具有很好的临床应用价值。

Serum zinc (Zn) and copper (Cu) levels were determined in 40 patients who were radically treated for breast carcinoma. Markedly higher serum Cu and lower Zn were observed (P<0.05) and the serum Cu/Zn ratio was significantly higher in recurrent group as compared to non-recurrent group (P<0.001). In the diagnosis for breast cancer recurrence, at a cutoff value of 1.54, Cu/Zn ratio had a sensitivity of 69%, specificity of 85% and diagnostic index of 0.54. when Cu/Zn ratio was combined with serum carcinoembryonic antigen (CEA), the aforementioned values were 91%, 75% and 0.66 respectively. It is suggested that serum Cu/Zn ratio, especially when combined with CEA, may be a helpful marker for the diagnosis of breast cancer recurrence.