摘要
采用粉体基础物性测定仪测定粉末直接压片工艺所用辅料的休止角、抹角、压缩度、凝聚度和均一度 ,了解粉末直接压片工艺所用辅料的流动性 ,为粉末直接压片工艺法提供工艺参数。结果表明 ,国产微晶纤维素凝聚现象较强 ,流动性指数最小 ;进口微晶纤维素几乎没有凝聚现象 ,流动性指数最高。AvicelPH1 0 2微晶纤维素和 4 0— 6
To approach flowability for direct compression the parameters of the diluents such as angle of repose, angle of spatula, aerated bulk density, packed bulk density, compressibility, cohesiveness, distribution of particle size and uniformity were determined. Flowability index of the diluents was calculated. Results shown as flowability index of lactose (40~60 M) and microcrystalline cellulose(Avicel PH102) are above 60, which possessed good compressibility and can meet the requirement of the process of direct compression.
出处
《科学技术与工程》
2004年第5期367-370,共4页
Science Technology and Engineering
基金
国家"九五"科技攻关项目 ( 96 90 2 0 2 17)资助