脑清宁颗粒剂对小鼠学习记忆能力的影响

Effects of Naoqingning granula on learning and memory in mice

目的 观察脑清宁颗粒刑对小鼠学习记忆能力的影响。方法 以东莨菪碱、亚硝酸钠和乙醇分别造成小鼠记忆获得障碍、记忆巩固障碍和记忆再现障碍,采用Y型迷路法测定小鼠学习记忆能力。结果 在3种记忆障碍模型中,预先灌胃给予脑清宁颗粒刑5、10、20g·kg^(-1),1次·d^(-1),连续7d,可明显提高小鼠的学习记忆成绩(P<0.001)。结论 脑清宁颗粒剂对小鼠学习记忆障碍有改善作用。

OBJECTIVE To determine the effects of Naoqingning Granula on learning and memory in mice. METHODS In the mouse model of dysmnesia induced by scopolamine, sodium nitrite (NaNO_2) and ethanol, the learning and memory were determined by Y type electricity maze test. RESULTS Pretreatment with Naoqingning Granula (5, 10, 20 g·kg^(-1)·ig. once a day for 7 d) significantly increased the achievement of learning and memory in the mouse model of dysmnesia (P<0.001). CONCLUSIONS Naoqingning Granula may improve the learning and memory in the mouse model of dysmnesia induced by chemicals.