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同型半胱氨酸及其代谢酶基因多态性与动脉粥样硬化和脑梗死 被引量：13

Homocysteine and Its Metabolic Enzyme Polymorphisms Versus Atherosclerosis and Cerebral Infarction
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摘要 高同型半胱氨酸血症是近年来提出的动脉粥样硬化及其血管并发症新的独立危险因素。造成血浆同型半胱氨酸水平升高的因素主要有营养因素和同型半胱氨酸代谢酶基因多态性 ,后者是否为动脉粥样硬化和脑梗死的基因危险因素目前还存在争论。对高同型半胱氨酸血症的治疗也进行了一些研究。 Hyperhomocysteinemia (Hhcy) is a new independent risk factor of atherosclerosis and its vascular complications, which was raised in recent years. The factors that cause the increase of homocysteine levels are primarily nutrition and homocysteine metabolic enzyme polymorphisms. Whether the latter is the gene risk factor of atherosclerosis and cerebral infarction is still controversial. The treatment of Hhcy is also studied.
作者 林小慧 李娜 董玉娟
机构地区 河北医科大学第三医院神经内科
出处 《国外医学（脑血管疾病分册）》 2004年第5期367-370,共4页 Foreign Medical Sciences Cerebrovascular Diseases
关键词 同型半胱氨酸 代谢酶 基因多态性 动脉粥样硬化 脑梗死 并发症 homocysteine ■ atherosclerosis ■ cerebral infarction ■ gene polymorphism
分类号 R543 [医药卫生—心血管疾病] R743.3 [医药卫生—神经病学与精神病学]
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参考文献31

  • 1张广森,戴崇文.缺血性心脑血管病患者血浆同型半胱氨酸水平及其代谢相关酶基因多态性分析[J].中华血液学杂志,2002,23(3):126-129. 被引量：65
  • 2Imueller T, Furtmueller B, Aigelsdorfer J, et al. Total serum homocysteine-a predictor of extracranial carotid artery stenosis in male patients with symptomatic peripheral arterial disease. Vasc Med, 2001,6:163 - 167.
  • 3McQuillan BM, Beilby JP, Nidorf M, et al. Hyperhomocysteinemia but not the C677T mutation of methylenetetrohydrofolate reductase is an independent risk determinant of carotid wall thickening. Circulation,1999, 99:2383 -2388.
  • 4Southern F, Edit J, Drouilbet J, et al. Increasing levels of dietary homocysteine with carotid endarterectomy produced proportio-nate increase in plasma homocysteine and intimal hyperplasia. Atherosclerosis, 2001, 158:129 - 138.
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二级参考文献9

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  • 9戴崇文,张广森.缺血性心、脑血管疾病患者同型半胱氨酸代谢相关酶基因突变频度的研究[J].中华血液学杂志,2001,22(9):484-487. 被引量：56

共引文献79

同被引文献148

引证文献13

二级引证文献83

国外医学（脑血管疾病分册）
2004年 第5期

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