摘要
目的观察双龙方对大鼠实验性心肌梗塞的治疗作用。方法采用冠状动脉结扎心肌梗塞模型,通过心肌梗塞面积的定量组织学测定、血管活性物质测定、心肌小血管密度等指标观测,评价给予双龙方14d后的双龙方治疗作用。结果双龙方给药14d后,心肌梗塞范围减小,6-keto-PGF1α/TXB2比值提高;心肌小血管的密度增加。结论双龙方对心肌梗塞有明确的治疗作用。
Objective To study the therapeutic effects of Shuanglong Prescription (SP) for experimental myocardial infarction in rats. Methods Rat models of myocardial infarction were induced by ligation of coronary artery. Fourteen days after treatment, myocardial infarction area, biochemical parameters and myocardial capillary density were detected to observe the effect of SP.Results After 14- day treatment, SP could reduce the area of myocardial infarction, increase the ratio of 6- keto- PGF1α and TXB2 and the capillary density.Conclusion SP has certain therapeutic effect for myocardial infarction in rats.
出处
《中药新药与临床药理》
CAS
CSCD
2004年第3期149-151,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金资助项目(编号30271663)。
关键词
双龙方
心肌梗塞
大鼠
Shuanglong prescription
Myocardial infarction
Rats
