摘要
目的观察急性应激对雌性大鼠生殖内分泌功能的影响。方法对成年雌性大鼠使用急性制动应激,观察应激后血浆雌二醇、孕酮及皮质酮含量变化。结果急性应激可使性成熟雌性大鼠性周期中各期血浆雌二醇水平显著降低,而血浆孕酮和皮质酮水平则显著升高,而且使二者比值严重失常,从而使雌性生殖内分泌陷入紊乱状态。结论本研究结果表明,急性应激可引起雌性生殖内分泌陷入紊乱状态。由于身心应激为女性生殖内分泌紊乱及相关疾病的重要诱因,急性制动应激(心理应激)引起雌性大鼠生殖内分泌功能紊乱的模型,可作为研究防止生殖内分泌功能紊乱性疾病药物的一种疾病动物模型。
Objective To observe the effects of acute stress on reproductive- endocrine function in female adult rats. Methods Acute immobilization stress was used to challenge the female adult rats and then the serum levels of progesterone (P), estradiol (E2) and corticosterone were measured 2 h after the stress.Results Acute stress significantly reduced E2 levels in each period of sexual cycle and increased the levels of P and corticosterone in the stressed rats.In addition, the ratio of estradiol and progesterone was disordered in stressed rats.Conclusion Acute stress can cause the disorder of estradiol and progesterone.Since stress is a major factor contributing to reproductive- endocrine disorder, this model will be useful for the research and development of drugs for reproductive- endocrine disorder.
出处
《中药新药与临床药理》
CAS
CSCD
2004年第3期155-157,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
江西省自然科学基金资助项目(编号994057)。
关键词
急性应激
雌二醇
孕酮
皮质酮
生殖内分泌紊乱
Acute stress
Estradiol
Progesterone
Corticosterone
Reproductive- endocrine disorder
