6,7-亚甲二氧基-9-甲基-1(2H,4H)-吖啶酮衍生物的合成

Synthesis of 6,7-Methylenedioxy-9-methyl-1(2H,4H)-acridone

以 5 芳基 1,3 环基环己二酮为原料合成了 8个未见报道的吖啶酮衍生物 ,其结构均经元素分析 ,IR和1HNMR光谱确证。其中 3 呋喃基 6 ,7 亚甲二氧基 9 甲基 1( 2H ,4H)

3-Aryl-6,7-methylenedioxy-9-methyl-1(2H,4H)-acridones and acridinols were synthesized from 5-aryl-1,3-cyclohexandione. The structures of the products were characterized by elemental analysis, IR and 1H NMR spectra. The preliminary parmacodynamic experiments show that 3-furyl-6,7-methylenedioxy-9-methyl-(2H,4H)-acridinol possesses a inhibition effect on the growth of cancer cell.