摘要
5-Fluorouracil salt(WBF) of 12-tungstoboric acid with Keggin structure was synthesized and its structure was characterized by IR, 1H NMR, 183 W NMR and elementary analysis. The MTT experimental results show that WBF has a stronger killing ability for liver cancer cells in vitro. The acute toxicity of WBF was carried out. The half toxicity dose LD_ 50 of WBF orally administrated to mice is 1 117.4 mg/kg. [WT5HZ]
5-Fluorouracil salt(WBF) of 12-tungstoboric acid with Keggin structure was synthesized and its structure was characterized by IR, 1H NMR, 183 W NMR and elementary analysis. The MTT experimental results show that WBF has a stronger killing ability for liver cancer cells in vitro. The acute toxicity of WBF was carried out. The half toxicity dose LD_ 50 of WBF orally administrated to mice is 1 117.4 mg/kg. [WT5HZ]
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2004年第6期1010-1012,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金 (批准号 :2 0 1710 10 )资助
关键词
钨硼酸
5-氟尿嘧啶
合成
抗癌活性
Tungstoboric acid
5-Fluorouracil
Synthesis
Anti-liver cancer activity
